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BAUSTIN VITAMIN POWER
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Western Diets Turn on Fat Genes
Those extra helpings of gravy and dessert at
the holiday table are even more of a problem to
your waistline than previously thought.
According to a new research report recently appearing online in
The FASEB Journal, a diet that is high in fat and in sugar actually
switches on genes that ultimately cause our bodies to store too
much fat.
These foods strike you with a double-problem as the task of converting high-fat and high-sugar
foods to energy is made even more difficult because these foods also turn our bodies into
"fat-storage containers."
In the research report, scientists show that foods high in fat and
sugar stimulate a known opioid receptor, called the kappa
opioid
receptor (KOR), which plays a role in fat metabolism. When this
receptor is stimulated, it causes our bodies to hang on to much
more fat than they'd do otherwise.
According to the researchers involved in the study, "the data presented here support the
hypothesis that overactivation of the kappa opioid receptors contribute to the development of
obesity, especially during prolonged consumption of high-fat, calorically
dense diets."
To make this discovery, the research team conducted tests in two groups of laboratory subjects. One
group had the kappa opioid receptor genetically deactivated and the other group was normal. Both
groups were given a high fat, high sucrose, energy dense diet for 16 weeks. While the control group
gained significant weight and fat mass on this diet, those with the deactivated receptor remained
lean. In addition to having reduced fat stores, those with the deactivated receptor also showed a
reduced ability to store incoming nutrients.
Although more work is required, this research may help address
the growing obesity problem worldwide in both the short-term and long-term. Most importantly, this
research provides more proof that high-fat and high-sugar diets should be avoided. In the
long-term, however, this research is even more significant, as it provides a specific target for
developing therapies for preventing obesity and helping obese people slim down.
"In times when food was scarce and starvation an ever-present threat, an adaptation that allows our
bodies to store as much energy as possible during plentiful times was probably a lifesaver.
Conversely, by removing that opioid receptor, we may have found a way to keep us from eating
ourselves to death." concluded the researchers.
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FASEB (The Federation of American
Societies for Experimental Biology) publishes online, Stanford University
Library.
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